Speaker

Dr. Doris Lacej

Biography :

1. Costa GM d’Angelo et al. investigated the transdermal delivery of vitamin D₃ using various chemical penetration enhancers in creams and gels, finding that high lipophilicity limits permeation and that retention in skin layers varies with formulation. 2. Alsaqr et al. evaluated the effect of different penetration enhancers on vitamin D₃ skin permeability across membranes and ex vivo porcine skin in Franz diffusion cells. 3. Kittaneh et al. prepared and evaluated film-forming solutions for vitamin D₃ transdermal delivery, showing permeation through artificial membranes with different polymer/solvent systems. 4. Vitamin D₃ stability and transdermal feasibility were examined with skin retention/permeation assays; results suggest limited permeation due to physicochemical properties like high lipophilicity. 5. Polymeric nanospheres (e.g., TyroSpheres) have been studied for topical delivery of vitamin D₃. These systems can enhance solubility, skin distribution, and stability against photodegradation, demonstrating the utility of particulate carriers for challenging lipophilic actives. 6. Lipid nanoparticles loaded with vitamin D₃ showed enhanced topical penetration and antioxidant properties, highlighting lipid-based carriers as promising for stability and delivery. 7. Nanostructured lipid carriers have also been assessed for transdermal vitamin D₃ delivery, showing improved stability and detectable permeation in ex vivo skin models. 8. General reviews on topical and transdermal drug delivery highlight the barrier function of the stratum corneum and the need for formulation strategies to enhance permeation of lipophilic compounds such as vitamin D₃. (e.g., Benson HA, Grice JE, Roberts MS — see PubMed sources referenced in other transdermal vitamin D literature). PubMed